Kumudini M Meepagala
USDA-ARS, USA
Title: Secondary metabolites with pesticide activity from plant pathogenic
Biography
Biography: Kumudini M Meepagala
Abstract
Phytopathogenic fungi produce secondary metabolites that are toxic to host plants. These fungi have evolved to survive in the ecological niche by producing secondary metabolites to compete with other fungi, plants and insects. Thus, these toxins can have various biological activities. As part of ongoing research efforts at USDA, we have investigated some plant pathogenic fungi in search of natural products that can be used as pesticides or can be used as lead compounds in designing such compounds. Phomalactone isolated from Nigrospora spherica, a plant pathogenic fungus isolated from Zinnia elegans and Hydrangea macrophylla, was found to be phytotoxic and mosquitocidal. From the culture medium of Curvularia intermedia, αβ-dehydrocurvularin was isolated as a phytotoxin. Pyricularia grisea is a fungus selective to monocots. From the culture broth of this fungus, pyrichalasin was isolated as the phytotoxin. A colony of three fungi was isolated from necrotic leaves of Basella alba, commonly known as Malabar Spinach. Diaporthe eres was isolated from infected Hedera helix leaves. An isocoumarins was isolated from the culture broth of this fungus and found to have phytotoxic and mosquito larvicidal activities. Based on this molecule, several analogs of isocoumarins were synthesized with higher phytotoxic activity. Isolation of active metabolites and synthesis of analogs will be discussed.